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Human Wilms tumor protein (aa 1-449)

WT1 Swiss Prot#

P19544

WT1 Protein names

Wilms tumor protein (WT33)

WT1 Gene names

WT1

Organism

Human

WT1 Entry name

WT1_HUMAN

WT1 Codon optimized cDNA(gene) Clone

WT1 Cat #

RPS0986

Tag

WT1 contains A 6x histidine tag

WT1 Formulation

Liquid

WT1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

WT1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant WT1 Protein

WT1 Cat #

PS0986

WT1 Source

recombinant

WT1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

WT1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

WT1 Activity

N/A

Tag

WT1 Contains A 6x histidine tag

WT1 Formulation

Liquid

WT1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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WT1 family

EGR C2H2-type zinc-finger protein family

WT1 Subcellular locations

Nucleus. Cytoplasm. Nucleus speckle. Nucleus > nucleoplasm.

WT1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.

WT1 Sequence

DDBJ

EMBL

GenBank

WT1 3D structure

ModBase

WT1 interaction

STRING

WT1 Proteomic

PRIDE

WT1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

WT1 Organism specific

CTD

MGI

WT1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

WT1 Gene expression

Bgee

ArrayExpress

Genevestigator

WT1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY