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Human Transcriptional enhancer factor TEF-4 (aa 1-447)

TEF4 Swiss Prot#

Q15562

TEF4 Protein names

Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2)

TEF4 Gene names

TEAD2 TEF4

Organism

Human

TEF4 Entry name

TEAD2_HUMAN

TEF4 Codon optimized cDNA(gene) Clone

TEF4 Cat #

RPS0885

Tag

TEF4 contains A 6x histidine tag

TEF4 Formulation

Liquid

TEF4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TEF4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TEF4 Protein

TEF4 Cat #

PS0885

TEF4 Source

recombinant

TEF4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TEF4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

TEF4 Activity

N/A

Tag

TEF4 Contains A 6x histidine tag

TEF4 Formulation

Liquid

TEF4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TEF4 family

-

TEF4 Subcellular locations

Nucleus.

TEF4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

TEF4 Sequence

DDBJ

EMBL

GenBank

TEF4 3D structure

ModBase

TEF4 interaction

STRING

TEF4 Proteomic

PRIDE

TEF4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

TEF4 Organism specific

CTD

MGI

TEF4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TEF4 Gene expression

Bgee

ArrayExpress

Genevestigator

TEF4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY