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Human Vacuolar-sorting protein SNF8 (aa 1-258)

EAP30 Swiss Prot#

Q96H20

EAP30 Protein names

Vacuolar-sorting protein SNF8 (ESCRT-II complex subunit VPS22) (hVps22) (ELL-associated protein of 30 kDa)

EAP30 Gene names

SNF8 EAP30

Organism

Human

EAP30 Entry name

SNF8_HUMAN

EAP30 Codon optimized cDNA(gene) Clone

EAP30 Cat #

RPS0794

Tag

EAP30 contains A 6x histidine tag

EAP30 Formulation

Liquid

EAP30 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

EAP30 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant EAP30 Protein

EAP30 Cat #

PS0794

EAP30 Source

recombinant

EAP30 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

EAP30 Purity

>90%, as determined by SDS-PAGE under reducing conditions

EAP30 Activity

N/A

Tag

EAP30 Contains A 6x histidine tag

EAP30 Formulation

Liquid

EAP30 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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EAP30 family

SNF8 family

EAP30 Subcellular locations

Cytoplasm. Endosome membrane. Nucleus. Late endosome membrane.

EAP30 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.

EAP30 Sequence

DDBJ

EMBL

GenBank

EAP30 3D structure

ModBase

EAP30 interaction

STRING

EAP30 Proteomic

PRIDE

EAP30 Genome annotation

Ensembl

GeneID

KEGG

UCSC

EAP30 Organism specific

CTD

MGI

EAP30 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

EAP30 Gene expression

Bgee

ArrayExpress

Genevestigator

EAP30 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY