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Human SWI SNF-related matrix-associated actin E 1 (aa 1-411)

BAF57 Swiss Prot#

Q969G3

BAF57 Protein names

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)

BAF57 Gene names

SMARCE1 BAF57

Organism

Human

BAF57 Entry name

SMCE1_HUMAN

BAF57 Codon optimized cDNA(gene) Clone

BAF57 Cat #

RPS0784

Tag

BAF57 contains A 6x histidine tag

BAF57 Formulation

Liquid

BAF57 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

BAF57 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant BAF57 Protein

BAF57 Cat #

PS0784

BAF57 Source

recombinant

BAF57 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

BAF57 Purity

>90%, as determined by SDS-PAGE under reducing conditions

BAF57 Activity

N/A

Tag

BAF57 Contains A 6x histidine tag

BAF57 Formulation

Liquid

BAF57 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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BAF57 family

-

BAF57 Subcellular locations

Nucleus.

BAF57 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

BAF57 Sequence

DDBJ

EMBL

GenBank

BAF57 3D structure

ModBase

BAF57 interaction

STRING

BAF57 Proteomic

PRIDE

BAF57 Genome annotation

Ensembl

GeneID

KEGG

UCSC

BAF57 Organism specific

CTD

MGI

BAF57 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BAF57 Gene expression

Bgee

ArrayExpress

Genevestigator

BAF57 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY