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Human NAD-dependent deacetylase sirtuin-6 (aa 1-355)
SIR2L6 Swiss Prot#
Q8N6T7
SIR2L6 Protein names
NAD-dependent deacetylase sirtuin-6 (EC 3.5.1.-) (SIR2-like protein 6)
SIR2L6 Gene names
SIRT6 SIR2L6
Organism
Human
SIR2L6 Entry name
SIRT6_HUMAN
SIR2L6 Codon optimized cDNA(gene) Clone
SIR2L6 Cat #
RPS0765
Tag
SIR2L6 contains A 6x histidine tag
SIR2L6 Formulation
Liquid
SIR2L6 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
SIR2L6 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant SIR2L6 Protein
SIR2L6 Cat #
PS0765
SIR2L6 Source
recombinant
SIR2L6 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
SIR2L6 Purity
>90%, as determined by SDS-PAGE under reducing conditions
SIR2L6 Activity
N/A
Tag
SIR2L6 Contains A 6x histidine tag
SIR2L6 Formulation
Liquid
SIR2L6 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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SIR2L6 family
Sirtuin family
SIR2L6 Subcellular locations
Nucleus > nucleoplasm.
SIR2L6 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein (By similarity).
SIR2L6 Sequence
DDBJ EMBL GenBank
SIR2L6 3D structure
ModBase
SIR2L6 interaction
STRING
SIR2L6 Proteomic
PRIDE
SIR2L6 Genome annotation
Ensembl GeneID KEGG UCSC
SIR2L6 Organism specific
CTD MGI
SIR2L6 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
SIR2L6 Gene expression
Bgee ArrayExpress Genevestigator
SIR2L6 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY