|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
||||||||||||||||||||||||||||||||||
|
|||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Human NAD-dependent deacetylase sirtuin-6 (aa 1-355) |
| SIR2L6 Swiss Prot# | | Q8N6T7 |
| SIR2L6 Protein names | | NAD-dependent deacetylase sirtuin-6 (EC 3.5.1.-) (SIR2-like protein 6) |
| SIR2L6 Gene names | | SIRT6 SIR2L6 |
| Organism | | Human |
| SIR2L6 Entry name | | SIRT6_HUMAN |
| SIR2L6 Codon optimized cDNA(gene) Clone |
| SIR2L6 Cat # | | RPS0765 |
| Tag | | SIR2L6 contains A 6x histidine tag |
| SIR2L6 Formulation | | Liquid |
| SIR2L6 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| SIR2L6 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant SIR2L6 Protein |
| SIR2L6 Cat # | | PS0765 |
| SIR2L6 Source | | recombinant |
| SIR2L6 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| SIR2L6 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| SIR2L6 Activity | | N/A |
| Tag | | SIR2L6 Contains A 6x histidine tag |
| SIR2L6 Formulation | | Liquid |
| SIR2L6 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant SIR2L6 Products | | For pricing and availability Click Here >>> |
| SIR2L6 family | | Sirtuin family |
| SIR2L6 Subcellular locations | | Nucleus > nucleoplasm. |
| SIR2L6 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein (By similarity). |
| SIR2L6 Sequence | | DDBJ | EMBL | GenBank |
| SIR2L6 3D structure | | ModBase |
| SIR2L6 interaction | | STRING |
| SIR2L6 Proteomic | | PRIDE |
| SIR2L6 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| SIR2L6 Organism specific | | CTD | MGI |
| SIR2L6 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| SIR2L6 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| SIR2L6 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |