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Human E3 ubiquitin-protein ligase SIAH2 (aa 1-324)

SIAH2 Swiss Prot#

O43255

SIAH2 Protein names

E3 ubiquitin-protein ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2)

SIAH2 Gene names

SIAH2

Organism

Human

SIAH2 Entry name

SIAH2_HUMAN

SIAH2 Codon optimized cDNA(gene) Clone

SIAH2 Cat #

RPS0761

Tag

SIAH2 contains A 6x histidine tag

SIAH2 Formulation

Liquid

SIAH2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SIAH2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SIAH2 Protein

SIAH2 Cat #

PS0761

SIAH2 Source

recombinant

SIAH2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SIAH2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

SIAH2 Activity

N/A

Tag

SIAH2 Contains A 6x histidine tag

SIAH2 Formulation

Liquid

SIAH2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SIAH2 family

SINA (Seven in absentia) family

SIAH2 Subcellular locations

Cytoplasm. Nucleus.

SIAH2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.

SIAH2 Sequence

DDBJ

EMBL

GenBank

SIAH2 3D structure

ModBase

SIAH2 interaction

STRING

SIAH2 Proteomic

PRIDE

SIAH2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

SIAH2 Organism specific

CTD

MGI

SIAH2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SIAH2 Gene expression

Bgee

ArrayExpress

Genevestigator

SIAH2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY