All rights reserved

Bio-Magnetic Purification ......   A Powerful Tool for Life Science Research Affinity Magnetic Beads >>> Amine >>                 Aldehyde >>                  Carboxy >>    CDI >>                      DVS >>                          DADPA  >>     Epoxy  >>                 Hydrazide >>                 Hyrdoxy >>     Iodoacetyl >>           NHS >>                         Sulghydry >> Tosyl >>                   Thiol >>                         Silica >> EDTA >>                   IDA >>                      Streptavidin  >> Monomer Avidin >>          Reversed-Phase Magnetic Beads >>> C4 >>                          C8 >>                       C18 >>   Cyanopropyl >>          Phenyl >>                 Dipheny >> Ion Exchange Magnetic Beads >>> DEAE >>                   PSA >>                  SAX >> WCX >>                    SCX >>           Hydroxyapatite  >> Antibody Purification & IP >>> Protein A >>           Protein G >>        Protein A/G >> Protein L >> Recombinant Protein Purification >>> Ni+ Charged Beads >>    Co + Charged Beads >> GST >> DNA & RNA Purification >>> Plant/Animal >>         Bacteria >>             Blood >> Saliva >>                   Stool >>                  Food >> mRNA >>                    PCR >>                   Soil >> Endotoxin Removal Magnetic Beads >>>   Abundant Protein Removal >>> HSA  Removal >>                                    IgG  Removal >> Cell Isolation >>> Bacteria >>                                              Viurs >> More Application >>

Home BioMagnetic Beads Recombinant Protein & Codon Optimized cDNA Service Order Contact Us New recombinant

For cDNA or Recombinant Protein Search ( Input   Gene name, or Protein Name, or Swiss -prot Accession Number Bioclone Distributor >>>

Email: info@bioclone.us ;  order@bioclone.us

More Than 20,000   Recombinant Protein & cDNA(gene) Virus Antigen  >>> Bacterial Antigen >>> Parasite Antigen  >>> Cell Surface CD Marker >> Cytokines >>> Kinase  >>> Transduction >>> Transcription Factor >>> Common Disease-related Proteins >>> Phosphatase >>> Cancer >>> Drug  metabolism >>> Neuroscience >>> G protein coupled receptors   >>> Stem cell >> Kinase >>> Disease >.>> Toxin & Allergen >>> Cytoskeleton >>

Human E3 ubiquitin-protein ligase SIAH1 (aa 1-282)

HUMSIAH Swiss Prot#

Q8IUQ4

HUMSIAH Protein names

E3 ubiquitin-protein ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)

HUMSIAH Gene names

SIAH1 HUMSIAH

Organism

Human

HUMSIAH Entry name

SIAH1_HUMAN

HUMSIAH Codon optimized cDNA(gene) Clone

HUMSIAH Cat #

RPS0760

Tag

HUMSIAH contains A 6x histidine tag

HUMSIAH Formulation

Liquid

HUMSIAH Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

HUMSIAH Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant HUMSIAH Protein

HUMSIAH Cat #

PS0760

HUMSIAH Source

recombinant

HUMSIAH Applications

Western Blot, SDS-Page or may be used for other applications determined by user

HUMSIAH Purity

>90%, as determined by SDS-PAGE under reducing conditions

HUMSIAH Activity

N/A

Tag

HUMSIAH Contains A 6x histidine tag

HUMSIAH Formulation

Liquid

HUMSIAH Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Place Order for Recombinant HUMSIAH Products

For pricing and availability Click Here >>>

HUMSIAH family

SINA (Seven in absentia) family

HUMSIAH Subcellular locations

Cytoplasm. Nucleus.

HUMSIAH FUNCTION According to UniProtKB Swiss Prot

FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.

HUMSIAH Sequence

DDBJ

EMBL

GenBank

HUMSIAH 3D structure

ModBase

HUMSIAH interaction

STRING

HUMSIAH Proteomic

PRIDE

HUMSIAH Genome annotation

Ensembl

GeneID

KEGG

UCSC

HUMSIAH Organism specific

CTD

MGI

HUMSIAH Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

HUMSIAH Gene expression

Bgee

ArrayExpress

Genevestigator

HUMSIAH Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY