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Human E3 ubiquitin-protein ligase RNF8 (aa 1-485)

RNF8 Swiss Prot#

O76064

RNF8 Protein names

E3 ubiquitin-protein ligase RNF8 (EC 6.3.2.-) (RING finger protein 8)

RNF8 Gene names

RNF8 KIAA0646

Organism

Human

RNF8 Entry name

RNF8_HUMAN

RNF8 Codon optimized cDNA(gene) Clone

RNF8 Cat #

RPS0730

Tag

RNF8 contains A 6x histidine tag

RNF8 Formulation

Liquid

RNF8 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RNF8 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RNF8 Protein

RNF8 Cat #

PS0730

RNF8 Source

recombinant

RNF8 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RNF8 Purity

>90%, as determined by SDS-PAGE under reducing conditions

RNF8 Activity

N/A

Tag

RNF8 Contains A 6x histidine tag

RNF8 Formulation

Liquid

RNF8 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RNF8 family

RNF8 family

RNF8 Subcellular locations

Nucleus. Midbody.

RNF8 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: E3 ubiquitin-protein ligase required for assembly of repair proteins to sites of DNA damage. Catalyzes the 'Lys-63'-linked ubiquitination of histone H2A and H2AX. Following DNA double-strand breaks (DSBs), it is recruited to the sites of damage by ATM-phosphorylated MDC1, mediates the ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBE2N/UBC13. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Enforces the G2/M DNA damage checkpoint. Controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites following DNA double-strand breaks (DSBs). Ubiquitination of histone H2A requires UBE2N but not MMS2 (UBE2V2). May also ubiquitinate histone H2B. Catalyzes the 'Lys-63'-linked ubiquitination of PCNA. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.

RNF8 Sequence

DDBJ

EMBL

GenBank

RNF8 3D structure

ModBase

RNF8 interaction

STRING

RNF8 Proteomic

PRIDE

RNF8 Genome annotation

Ensembl

GeneID

KEGG

UCSC

RNF8 Organism specific

CTD

MGI

RNF8 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RNF8 Gene expression

Bgee

ArrayExpress

Genevestigator

RNF8 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY