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Human E3 ubiquitin-protein ligase NRDP1 (aa 1-317)

FLRF Swiss Prot#

Q9H4P4

FLRF Protein names

E3 ubiquitin-protein ligase NRDP1 (EC 6.3.2.-) (RING finger protein 41)

FLRF Gene names

RNF41 FLRF NRDP1 SBBI03

Organism

Human

FLRF Entry name

RNF41_HUMAN

FLRF Codon optimized cDNA(gene) Clone

FLRF Cat #

RPS0728

Tag

FLRF contains A 6x histidine tag

FLRF Formulation

Liquid

FLRF Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

FLRF Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant FLRF Protein

FLRF Cat #

PS0728

FLRF Source

recombinant

FLRF Applications

Western Blot, SDS-Page or may be used for other applications determined by user

FLRF Purity

>90%, as determined by SDS-PAGE under reducing conditions

FLRF Activity

N/A

Tag

FLRF Contains A 6x histidine tag

FLRF Formulation

Liquid

FLRF Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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FLRF family

-

FLRF Subcellular locations

-

FLRF FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, FLRF is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.

FLRF Sequence

DDBJ

EMBL

GenBank

FLRF 3D structure

ModBase

FLRF interaction

STRING

FLRF Proteomic

PRIDE

FLRF Genome annotation

Ensembl

GeneID

KEGG

UCSC

FLRF Organism specific

CTD

MGI

FLRF Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

FLRF Gene expression

Bgee

ArrayExpress

Genevestigator

FLRF Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY