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  • For cDNA or Recombinant Protein Search ( Input  
    Gene name, or Protein Name, or Swiss -prot Accession
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Human E3 ubiquitin-protein ligase RING1 (aa 1-406)
RNF1 Swiss Prot#
Q06587
RNF1 Protein names
E3 ubiquitin-protein ligase RING1 (EC 6.3.2.-) (RING finger protein 1) (Polycomb complex protein RING1) (Really interesting new gene 1 protein)
RNF1 Gene names
RING1 RNF1
Organism
Human
RNF1 Entry name
RING1_HUMAN
RNF1 Codon optimized cDNA(gene) Clone
RNF1 Cat #
RPS0714
Tag
RNF1 contains A 6x histidine tag
RNF1 Formulation
Liquid
RNF1 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
RNF1 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant RNF1 Protein
RNF1 Cat #
PS0714
RNF1 Source
recombinant
RNF1 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
RNF1 Purity
>90%, as determined by SDS-PAGE under reducing conditions
RNF1 Activity
N/A
Tag
RNF1 Contains A 6x histidine tag
RNF1 Formulation
Liquid
RNF1 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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RNF1 family
-
RNF1 Subcellular locations
Nucleus speckle.
RNF1 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
RNF1 Sequence
DDBJ EMBL GenBank
RNF1 3D structure
ModBase
RNF1 interaction
STRING
RNF1 Proteomic
PRIDE
RNF1 Genome annotation
Ensembl GeneID KEGG UCSC
RNF1 Organism specific
CTD MGI
RNF1 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
RNF1 Gene expression
Bgee ArrayExpress Genevestigator
RNF1 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY