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| Human E3 ubiquitin-protein ligase RING1 (aa 1-406) |
| RNF1 Swiss Prot# | | Q06587 |
| RNF1 Protein names | | E3 ubiquitin-protein ligase RING1 (EC 6.3.2.-) (RING finger protein 1) (Polycomb complex protein RING1) (Really interesting new gene 1 protein) |
| RNF1 Gene names | | RING1 RNF1 |
| Organism | | Human |
| RNF1 Entry name | | RING1_HUMAN |
| RNF1 Codon optimized cDNA(gene) Clone |
| RNF1 Cat # | | RPS0714 |
| Tag | | RNF1 contains A 6x histidine tag |
| RNF1 Formulation | | Liquid |
| RNF1 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| RNF1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant RNF1 Protein |
| RNF1 Cat # | | PS0714 |
| RNF1 Source | | recombinant |
| RNF1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| RNF1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| RNF1 Activity | | N/A |
| Tag | | RNF1 Contains A 6x histidine tag |
| RNF1 Formulation | | Liquid |
| RNF1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant RNF1 Products | | For pricing and availability Click Here >>> |
| RNF1 family | | - |
| RNF1 Subcellular locations | | Nucleus speckle. |
| RNF1 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. |
| RNF1 Sequence | | DDBJ | EMBL | GenBank |
| RNF1 3D structure | | ModBase |
| RNF1 interaction | | STRING |
| RNF1 Proteomic | | PRIDE |
| RNF1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| RNF1 Organism specific | | CTD | MGI |
| RNF1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| RNF1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| RNF1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |