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| Human Nuclear receptor subfamily 2 group F member 6 (aa 1-404) |
| EAR2 Swiss Prot# | | P10588 |
| EAR2 Protein names | | Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) |
| EAR2 Gene names | | NR2F6 EAR2 ERBAL2 |
| Organism | | Human |
| EAR2 Entry name | | NR2F6_HUMAN |
| EAR2 Codon optimized cDNA(gene) Clone |
| EAR2 Cat # | | RPS0580 |
| Tag | | EAR2 contains A 6x histidine tag |
| EAR2 Formulation | | Liquid |
| EAR2 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| EAR2 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant EAR2 Protein |
| EAR2 Cat # | | PS0580 |
| EAR2 Source | | recombinant |
| EAR2 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| EAR2 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| EAR2 Activity | | N/A |
| Tag | | EAR2 Contains A 6x histidine tag |
| EAR2 Formulation | | Liquid |
| EAR2 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant EAR2 Products | | For pricing and availability Click Here >>> |
| EAR2 family | | Nuclear hormone receptor family, NR2 subfamily |
| EAR2 Subcellular locations | | Nucleus. |
| EAR2 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). |
| EAR2 Sequence | | DDBJ | EMBL | GenBank |
| EAR2 3D structure | | ModBase |
| EAR2 interaction | | STRING |
| EAR2 Proteomic | | PRIDE |
| EAR2 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| EAR2 Organism specific | | CTD | MGI |
| EAR2 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| EAR2 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| EAR2 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |