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Human Nuclear receptor subfamily 2 group F member 6 (aa 1-404)
EAR2 Swiss Prot#
P10588
EAR2 Protein names
Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2)
EAR2 Gene names
NR2F6 EAR2 ERBAL2
Organism
Human
EAR2 Entry name
NR2F6_HUMAN
EAR2 Codon optimized cDNA(gene) Clone
EAR2 Cat #
RPS0580
Tag
EAR2 contains A 6x histidine tag
EAR2 Formulation
Liquid
EAR2 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
EAR2 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant EAR2 Protein
EAR2 Cat #
PS0580
EAR2 Source
recombinant
EAR2 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
EAR2 Purity
>90%, as determined by SDS-PAGE under reducing conditions
EAR2 Activity
N/A
Tag
EAR2 Contains A 6x histidine tag
EAR2 Formulation
Liquid
EAR2 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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EAR2 family
Nuclear hormone receptor family, NR2 subfamily
EAR2 Subcellular locations
Nucleus.
EAR2 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
EAR2 Sequence
DDBJ EMBL GenBank
EAR2 3D structure
ModBase
EAR2 interaction
STRING
EAR2 Proteomic
PRIDE
EAR2 Genome annotation
Ensembl GeneID KEGG UCSC
EAR2 Organism specific
CTD MGI
EAR2 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
EAR2 Gene expression
Bgee ArrayExpress Genevestigator
EAR2 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY