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Human Methyl-CpG-binding domain protein 2 (aa 1-411)

MBD2 Swiss Prot#

Q9UBB5

MBD2 Protein names

Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2) (Demethylase) (DMTase)

MBD2 Gene names

MBD2

Organism

Human

MBD2 Entry name

MBD2_HUMAN

MBD2 Codon optimized cDNA(gene) Clone

MBD2 Cat #

RPS0476

Tag

MBD2 contains A 6x histidine tag

MBD2 Formulation

Liquid

MBD2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MBD2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MBD2 Protein

MBD2 Cat #

PS0476

MBD2 Source

recombinant

MBD2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MBD2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MBD2 Activity

N/A

Tag

MBD2 Contains A 6x histidine tag

MBD2 Formulation

Liquid

MBD2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MBD2 family

-

MBD2 Subcellular locations

Nucleus.

MBD2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemi-methylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Isoform 1 may enhance the activation of some unmethylated cAMP-responsive promoters. Reports about DNA demethylase activity of isoform 2 are contradictory.

MBD2 Sequence

DDBJ

EMBL

GenBank

MBD2 3D structure

ModBase

MBD2 interaction

STRING

MBD2 Proteomic

PRIDE

MBD2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MBD2 Organism specific

CTD

MGI

MBD2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MBD2 Gene expression

Bgee

ArrayExpress

Genevestigator

MBD2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY