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Human Histone acetyltransferase KAT5 (aa 1-513)

HTATIP Swiss Prot#

Q92993

HTATIP Protein names

Histone acetyltransferase KAT5 (EC 2.3.1.48) (Lysine acetyltransferase 5) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (60 kDa Tat-interactive protein) (Tip60) (cPLA(2)-interacting protein)

HTATIP Gene names

KAT5 HTATIP TIP60

Organism

Human

HTATIP Entry name

KAT5_HUMAN

HTATIP Codon optimized cDNA(gene) Clone

HTATIP Cat #

RPS0407

Tag

HTATIP contains A 6x histidine tag

HTATIP Formulation

Liquid

HTATIP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

HTATIP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant HTATIP Protein

HTATIP Cat #

PS0407

HTATIP Source

recombinant

HTATIP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

HTATIP Purity

>90%, as determined by SDS-PAGE under reducing conditions

HTATIP Activity

N/A

Tag

HTATIP Contains A 6x histidine tag

HTATIP Formulation

Liquid

HTATIP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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HTATIP family

MYST (SAS/MOZ) family

HTATIP Subcellular locations

Nucleus > nucleolus. Cytoplasm > perinuclear region.

HTATIP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

HTATIP Sequence

DDBJ

EMBL

GenBank

HTATIP 3D structure

ModBase

HTATIP interaction

STRING

HTATIP Proteomic

PRIDE

HTATIP Genome annotation

Ensembl

GeneID

KEGG

UCSC

HTATIP Organism specific

CTD

MGI

HTATIP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

HTATIP Gene expression

Bgee

ArrayExpress

Genevestigator

HTATIP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY