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Human DNA-binding protein Ikaros (aa 1-519)

IK1 Swiss Prot#

Q13422

IK1 Protein names

DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)

IK1 Gene names

IKZF1 IK1 IKAROS LYF1 ZNFN1A1

Organism

Human

IK1 Entry name

IKZF1_HUMAN

IK1 Codon optimized cDNA(gene) Clone

IK1 Cat #

RPS0374

Tag

IK1 contains A 6x histidine tag

IK1 Formulation

Liquid

IK1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

IK1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant IK1 Protein

IK1 Cat #

PS0374

IK1 Source

recombinant

IK1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

IK1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

IK1 Activity

N/A

Tag

IK1 Contains A 6x histidine tag

IK1 Formulation

Liquid

IK1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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IK1 family

Ikaros C2H2-type zinc-finger protein family

IK1 Subcellular locations

Nucleus. Cytoplasm.

IK1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity).

IK1 Sequence

DDBJ

EMBL

GenBank

IK1 3D structure

ModBase

IK1 interaction

STRING

IK1 Proteomic

PRIDE

IK1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

IK1 Organism specific

CTD

MGI

IK1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

IK1 Gene expression

Bgee

ArrayExpress

Genevestigator

IK1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY