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| Human Hypoxia-inducible factor 1-alpha inhibitor (aa 1-349) |
| FIH1 Swiss Prot# | | Q9NWT6 |
| FIH1 Protein names | | Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.16) (Hypoxia-inducible factor asparagine hydroxylase) (Factor inhibiting HIF-1) (FIH-1) |
| FIH1 Gene names | | HIF1AN FIH1 |
| Organism | | Human |
| FIH1 Entry name | | HIF1N_HUMAN |
| FIH1 Codon optimized cDNA(gene) Clone |
| FIH1 Cat # | | RPS0306 |
| Tag | | FIH1 contains A 6x histidine tag |
| FIH1 Formulation | | Liquid |
| FIH1 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| FIH1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant FIH1 Protein |
| FIH1 Cat # | | PS0306 |
| FIH1 Source | | recombinant |
| FIH1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| FIH1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| FIH1 Activity | | N/A |
| Tag | | FIH1 Contains A 6x histidine tag |
| FIH1 Formulation | | Liquid |
| FIH1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant FIH1 Products | | For pricing and availability Click Here >>> |
| FIH1 family | | - |
| FIH1 Subcellular locations | | Nucleus. |
| FIH1 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. |
| FIH1 Sequence | | DDBJ | EMBL | GenBank |
| FIH1 3D structure | | ModBase |
| FIH1 interaction | | STRING |
| FIH1 Proteomic | | PRIDE |
| FIH1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| FIH1 Organism specific | | CTD | MGI |
| FIH1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| FIH1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| FIH1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |