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Human Hypoxia-inducible factor 1-alpha inhibitor (aa 1-349)
FIH1 Swiss Prot#
Q9NWT6
FIH1 Protein names
Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.16) (Hypoxia-inducible factor asparagine hydroxylase) (Factor inhibiting HIF-1) (FIH-1)
FIH1 Gene names
HIF1AN FIH1
Organism
Human
FIH1 Entry name
HIF1N_HUMAN
FIH1 Codon optimized cDNA(gene) Clone
FIH1 Cat #
RPS0306
Tag
FIH1 contains A 6x histidine tag
FIH1 Formulation
Liquid
FIH1 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
FIH1 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant FIH1 Protein
FIH1 Cat #
PS0306
FIH1 Source
recombinant
FIH1 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
FIH1 Purity
>90%, as determined by SDS-PAGE under reducing conditions
FIH1 Activity
N/A
Tag
FIH1 Contains A 6x histidine tag
FIH1 Formulation
Liquid
FIH1 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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FIH1 family
-
FIH1 Subcellular locations
Nucleus.
FIH1 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases.
FIH1 Sequence
DDBJ EMBL GenBank
FIH1 3D structure
ModBase
FIH1 interaction
STRING
FIH1 Proteomic
PRIDE
FIH1 Genome annotation
Ensembl GeneID KEGG UCSC
FIH1 Organism specific
CTD MGI
FIH1 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
FIH1 Gene expression
Bgee ArrayExpress Genevestigator
FIH1 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY