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Human DNA excision repair protein ERCC-8 (aa 1-396)

CKN1 Swiss Prot#

Q13216

CKN1 Protein names

DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)

CKN1 Gene names

ERCC8 CKN1 CSA

Organism

Human

CKN1 Entry name

ERCC8_HUMAN

CKN1 Codon optimized cDNA(gene) Clone

CKN1 Cat #

RPS0189

Tag

CKN1 contains A 6x histidine tag

CKN1 Formulation

Liquid

CKN1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CKN1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CKN1 Protein

CKN1 Cat #

PS0189

CKN1 Source

recombinant

CKN1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CKN1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CKN1 Activity

N/A

Tag

CKN1 Contains A 6x histidine tag

CKN1 Formulation

Liquid

CKN1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CKN1 family

-

CKN1 Subcellular locations

Nucleus.

CKN1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitement of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.

CKN1 Sequence

DDBJ

EMBL

GenBank

CKN1 3D structure

ModBase

CKN1 interaction

STRING

CKN1 Proteomic

PRIDE

CKN1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CKN1 Organism specific

CTD

MGI

CKN1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CKN1 Gene expression

Bgee

ArrayExpress

Genevestigator

CKN1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY