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Human Interferon-induced double-stranded RNA-activated (aa 1-551)

PKR Swiss Prot#

P19525

PKR Protein names

Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase)

PKR Gene names

EIF2AK2 PKR PRKR

Organism

Human

PKR Entry name

E2AK2_HUMAN

PKR Codon optimized cDNA(gene) Clone

PKR Cat #

RPS0175

Tag

PKR contains A 6x histidine tag

PKR Formulation

Liquid

PKR Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PKR Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PKR Protein

PKR Cat #

PS0175

PKR Source

recombinant

PKR Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PKR Purity

>90%, as determined by SDS-PAGE under reducing conditions

PKR Activity

N/A

Tag

PKR Contains A 6x histidine tag

PKR Formulation

Liquid

PKR Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PKR family

Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily

PKR Subcellular locations

-

PKR FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

PKR Sequence

DDBJ

EMBL

GenBank

PKR 3D structure

ModBase

PKR interaction

STRING

PKR Proteomic

PRIDE

PKR Genome annotation

Ensembl

GeneID

KEGG

UCSC

PKR Organism specific

CTD

MGI

PKR Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PKR Gene expression

Bgee

ArrayExpress

Genevestigator

PKR Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY