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Human Egl nine homolog 2 (aa 1-407)

EIT6 Swiss Prot#

Q96KS0

EIT6 Protein names

Egl nine homolog 2 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-prolyl hydroxylase 1) (HIF-PH1) (HPH-1) (HPH-3) (Prolyl hydroxylase domain-containing protein 1) (PHD1) (Estrogen-induced tag 6)

EIT6 Gene names

EGLN2 EIT6

Organism

Human

EIT6 Entry name

EGLN2_HUMAN

EIT6 Codon optimized cDNA(gene) Clone

EIT6 Cat #

RPS0168

Tag

EIT6 contains A 6x histidine tag

EIT6 Formulation

Liquid

EIT6 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

EIT6 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant EIT6 Protein

EIT6 Cat #

PS0168

EIT6 Source

recombinant

EIT6 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

EIT6 Purity

>90%, as determined by SDS-PAGE under reducing conditions

EIT6 Activity

N/A

Tag

EIT6 Contains A 6x histidine tag

EIT6 Formulation

Liquid

EIT6 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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EIT6 family

-

EIT6 Subcellular locations

Cytoplasm. Nucleus.

EIT6 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation. Isoform p40 and isoform p43 exhibit the same level of activity.

EIT6 Sequence

DDBJ

EMBL

GenBank

EIT6 3D structure

ModBase

EIT6 interaction

STRING

EIT6 Proteomic

PRIDE

EIT6 Genome annotation

Ensembl

GeneID

KEGG

UCSC

EIT6 Organism specific

CTD

MGI

EIT6 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

EIT6 Gene expression

Bgee

ArrayExpress

Genevestigator

EIT6 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY