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Human Egl nine homolog 1 (aa 1-426)

C1orf12 Swiss Prot#

Q9GZT9

C1orf12 Protein names

Egl nine homolog 1 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)

C1orf12 Gene names

EGLN1 C1orf12 PNAS-118 PNAS-137

Organism

Human

C1orf12 Entry name

EGLN1_HUMAN

C1orf12 Codon optimized cDNA(gene) Clone

C1orf12 Cat #

RPS0167

Tag

C1orf12 contains A 6x histidine tag

C1orf12 Formulation

Liquid

C1orf12 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

C1orf12 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant C1orf12 Protein

C1orf12 Cat #

PS0167

C1orf12 Source

recombinant

C1orf12 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

C1orf12 Purity

>90%, as determined by SDS-PAGE under reducing conditions

C1orf12 Activity

N/A

Tag

C1orf12 Contains A 6x histidine tag

C1orf12 Formulation

Liquid

C1orf12 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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C1orf12 family

-

C1orf12 Subcellular locations

-

C1orf12 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

C1orf12 Sequence

DDBJ

EMBL

GenBank

C1orf12 3D structure

ModBase

C1orf12 interaction

STRING

C1orf12 Proteomic

PRIDE

C1orf12 Genome annotation

Ensembl

GeneID

KEGG

UCSC

C1orf12 Organism specific

CTD

MGI

C1orf12 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

C1orf12 Gene expression

Bgee

ArrayExpress

Genevestigator

C1orf12 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY