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Human Deformed epidermal autoregulatory factor 1 (aa 1-565)

SPN Swiss Prot#

O75398

SPN Protein names

Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5)

SPN Gene names

DEAF1 SPN ZMYND5

Organism

Human

SPN Entry name

DEAF1_HUMAN

SPN Codon optimized cDNA(gene) Clone

SPN Cat #

RPS0126

Tag

SPN contains A 6x histidine tag

SPN Formulation

Liquid

SPN Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SPN Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SPN Protein

SPN Cat #

PS0126

SPN Source

recombinant

SPN Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SPN Purity

>90%, as determined by SDS-PAGE under reducing conditions

SPN Activity

N/A

Tag

SPN Contains A 6x histidine tag

SPN Formulation

Liquid

SPN Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SPN family

-

SPN Subcellular locations

Nucleus. Cytoplasm. Secreted. Cytoplasm. Nucleus.

SPN FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm.

SPN Sequence

DDBJ

EMBL

GenBank

SPN 3D structure

ModBase

SPN interaction

STRING

SPN Proteomic

PRIDE

SPN Genome annotation

Ensembl

GeneID

KEGG

UCSC

SPN Organism specific

CTD

MGI

SPN Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SPN Gene expression

Bgee

ArrayExpress

Genevestigator

SPN Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY