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Human COP9 signalosome complex subunit 5 (aa 1-334)

CSN5 Swiss Prot#

Q92905

CSN5 Protein names

COP9 signalosome complex subunit 5 (Signalosome subunit 5) (SGN5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)

CSN5 Gene names

COPS5 CSN5 JAB1

Organism

Human

CSN5 Entry name

CSN5_HUMAN

CSN5 Codon optimized cDNA(gene) Clone

CSN5 Cat #

RPS0104

Tag

CSN5 contains A 6x histidine tag

CSN5 Formulation

Liquid

CSN5 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CSN5 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CSN5 Protein

CSN5 Cat #

PS0104

CSN5 Source

recombinant

CSN5 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CSN5 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CSN5 Activity

N/A

Tag

CSN5 Contains A 6x histidine tag

CSN5 Formulation

Liquid

CSN5 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CSN5 family

Peptidase M67A family, CSN5 subfamily

CSN5 Subcellular locations

Cytoplasm. Nucleus.

CSN5 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex.

CSN5 Sequence

DDBJ

EMBL

GenBank

CSN5 3D structure

ModBase

CSN5 interaction

STRING

CSN5 Proteomic

PRIDE

CSN5 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CSN5 Organism specific

CTD

MGI

CSN5 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CSN5 Gene expression

Bgee

ArrayExpress

Genevestigator

CSN5 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY