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STRPY Streptopain (aa 28-398)

speB Swiss Prot#

P0C0J0

speB Protein names

Streptopain (EC 3.4.22.10) (Streptococcal cysteine proteinase) (Streptococcus peptidase A) (SPP) (Exotoxin type B) (SPE B)

speB Gene names

speB

Organism

Streptococcus pyogenes

speB Entry name

SPEB_STRPY

speB Codon optimized cDNA(gene) Clone

speB Cat #

RPQ0176

Tag

speB contains A 6x histidine tag

speB Formulation

Liquid

speB Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

speB Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant speB Protein

speB Cat #

PQ0176

speB Source

recombinant

speB Applications

Western Blot, SDS-Page or may be used for other applications determined by user

speB Purity

>90%, as determined by SDS-PAGE under reducing conditions

speB Activity

N/A

Tag

speB Contains A 6x histidine tag

speB Formulation

Liquid

speB Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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speB family

Peptidase C10 family

speB Subcellular locations

Secreted.

speB FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.

speB Sequence

DDBJ

EMBL

GenBank

speB 3D structure

ModBase

speB interaction

STRING

speB Proteomic

PRIDE

speB Genome annotation

Ensembl

GeneID

KEGG

UCSC

speB Organism specific

CTD

MGI

speB Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

speB Gene expression

Bgee

ArrayExpress

Genevestigator

speB Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY