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PASHA Leukotoxin (aa 1-953)

lktA Swiss Prot#

Q7BHI8

lktA Protein names

Leukotoxin (Lkt)

lktA Gene names

lktA

Organism

Pasteurella haemolytica (Mannheimia haemolytica)

lktA Entry name

LKA1B_PASHA

lktA Codon optimized cDNA(gene) Clone

lktA Cat #

RPQ0138

Tag

lktA contains A 6x histidine tag

lktA Formulation

Liquid

lktA Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

lktA Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant lktA Protein

lktA Cat #

PQ0138

lktA Source

recombinant

lktA Applications

Western Blot, SDS-Page or may be used for other applications determined by user

lktA Purity

>90%, as determined by SDS-PAGE under reducing conditions

lktA Activity

N/A

Tag

lktA Contains A 6x histidine tag

lktA Formulation

Liquid

lktA Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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lktA family

RTX prokaryotic toxin (TC 1.C.11) family

lktA Subcellular locations

Secreted. Host cell membrane; Multi-pass membrane protein.

lktA FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell. This leukotoxin is a major contributor to the pathogenesis of lung injury in bovine pneumonic pasteurellosis. It has also week hemolytic activity.

lktA Sequence

DDBJ

EMBL

GenBank

lktA 3D structure

ModBase

lktA interaction

STRING

lktA Proteomic

PRIDE

lktA Genome annotation

Ensembl

GeneID

KEGG

UCSC

lktA Organism specific

CTD

MGI

lktA Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

lktA Gene expression

Bgee

ArrayExpress

Genevestigator

lktA Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY