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Rat Ephrin-A1 (aa 18-205)
Epgl1 Swiss Prot#
P97553
Epgl1 Protein names
Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61)
Epgl1 Gene names
Efna1 (Epgl1) (Lerk1)
Organism
Rat
Epgl1 Entry name
EFNA1_RAT
Epgl1 Codon optimized cDNA(gene) Clone
Epgl1 Cat #
RPU0373
Tag
Epgl1 contains A 6x histidine tag
Epgl1 Formulation
Liquid
Epgl1 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Epgl1 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Epgl1 Protein
Epgl1 Cat #
PU0373
Epgl1 Source
recombinant
Epgl1 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
Epgl1 Purity
>90%, as determined by SDS-PAGE under reducing conditions
Epgl1 Activity
N/A
Tag
Epgl1 Contains A 6x histidine tag
Epgl1 Formulation
Liquid
Epgl1 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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Epgl1 family
Ephrin family
Epgl1 Subcellular locations
Cell membrane; Lipid-anchor > GPI-anchor. Secreted.
Epgl1 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones (By similarity).
Epgl1 Sequence
DDBJ EMBL GenBank
Epgl1 3D structure
ModBase
Epgl1 interaction
STRING
Epgl1 Proteomic
PRIDE
Epgl1 Genome annotation
Ensembl GeneID KEGG UCSC
Epgl1 Organism specific
CTD MGI
Epgl1 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Epgl1 Gene expression
Bgee ArrayExpress Genevestigator
Epgl1 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY