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Mouse Runt-related transcription factor 1 (aa 1-451)

Aml1 Swiss Prot#

Q03347

Aml1 Protein names

Runt-related transcription factor 1 (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)

Aml1 Gene names

Runx1 (Aml1) (Cbfa2) (Pebp2ab)

Organism

Mouse

Aml1 Entry name

RUNX1_MOUSE

Aml1 Codon optimized cDNA(gene) Clone

Aml1 Cat #

RPU0315

Tag

Aml1 contains A 6x histidine tag

Aml1 Formulation

Liquid

Aml1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Aml1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Aml1 Protein

Aml1 Cat #

PU0315

Aml1 Source

recombinant

Aml1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Aml1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Aml1 Activity

N/A

Tag

Aml1 Contains A 6x histidine tag

Aml1 Formulation

Liquid

Aml1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Aml1 family

-

Aml1 Subcellular locations

Nucleus.

Aml1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits MYST4-dependent transcriptional activation (By similarity).

Aml1 Sequence

DDBJ

EMBL

GenBank

Aml1 3D structure

ModBase

Aml1 interaction

STRING

Aml1 Proteomic

PRIDE

Aml1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Aml1 Organism specific

CTD

MGI

Aml1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Aml1 Gene expression

Bgee

ArrayExpress

Genevestigator

Aml1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY