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| Mouse Phosphatidylinositol-3 4 5-trisphosphate PTEN (aa 1-403) |
| Mmac1 Swiss Prot# | | O08586 |
| Mmac1 Protein names | | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) |
| Mmac1 Gene names | | Pten (Mmac1) |
| Organism | | Mouse |
| Mmac1 Entry name | | PTEN_MOUSE |
| Mmac1 Codon optimized cDNA(gene) Clone |
| Mmac1 Cat # | | RPU0276 |
| Tag | | Mmac1 contains A 6x histidine tag |
| Mmac1 Formulation | | Liquid |
| Mmac1 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Mmac1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Mmac1 Protein |
| Mmac1 Cat # | | PU0276 |
| Mmac1 Source | | recombinant |
| Mmac1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Mmac1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Mmac1 Activity | | N/A |
| Tag | | Mmac1 Contains A 6x histidine tag |
| Mmac1 Formulation | | Liquid |
| Mmac1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Mmac1 Products | | For pricing and availability Click Here >>> |
| Mmac1 family | | - |
| Mmac1 Subcellular locations | | Cytoplasm. Nucleus. Nucleus > PML body. |
| Mmac1 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. |
| Mmac1 Sequence | | DDBJ | EMBL | GenBank |
| Mmac1 3D structure | | ModBase |
| Mmac1 interaction | | STRING |
| Mmac1 Proteomic | | PRIDE |
| Mmac1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Mmac1 Organism specific | | CTD | MGI |
| Mmac1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Mmac1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Mmac1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
