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| Mouse Lin-28 homolog A (aa 1-209) |
| Lin28a Swiss Prot# | | Q8K3Y3 |
| Lin28a Protein names | | Lin-28 homolog A (Testis-expressed protein 17) |
| Lin28a Gene names | | Lin28 (Lin28a) (Tex17) |
| Organism | | Mouse |
| Lin28a Entry name | | LN28A_MOUSE |
| Lin28a Codon optimized cDNA(gene) Clone |
| Lin28a Cat # | | RPU0240 |
| Tag | | Lin28a contains A 6x histidine tag |
| Lin28a Formulation | | Liquid |
| Lin28a Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Lin28a Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Lin28a Protein |
| Lin28a Cat # | | PU0240 |
| Lin28a Source | | recombinant |
| Lin28a Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Lin28a Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Lin28a Activity | | N/A |
| Tag | | Lin28a Contains A 6x histidine tag |
| Lin28a Formulation | | Liquid |
| Lin28a Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Lin28a Products | | For pricing and availability Click Here >>> |
| Lin28a family | | Lin-28 family |
| Lin28a Subcellular locations | | Cytoplasm. Nucleus > nucleolus. |
| Lin28a FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, Lin28a down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. |
| Lin28a Sequence | | DDBJ | EMBL | GenBank |
| Lin28a 3D structure | | ModBase |
| Lin28a interaction | | STRING |
| Lin28a Proteomic | | PRIDE |
| Lin28a Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Lin28a Organism specific | | CTD | MGI |
| Lin28a Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Lin28a Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Lin28a Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
