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Mouse Inducible T-cell costimulator (aa 21-200)

Ailim Swiss Prot#

Q9WVS0

Ailim Protein names

Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD28 and CTLA-4-like protein) (CCLP) (CD28-related protein 1) (CRP-1) (CD antigen CD278)

Ailim Gene names

Icos (Ailim)

Organism

Mouse

Ailim Entry name

ICOS_MOUSE

Ailim Codon optimized cDNA(gene) Clone

Ailim Cat #

RPU0221

Tag

Ailim contains A 6x histidine tag

Ailim Formulation

Liquid

Ailim Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Ailim Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Ailim Protein

Ailim Cat #

PU0221

Ailim Source

recombinant

Ailim Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Ailim Purity

>90%, as determined by SDS-PAGE under reducing conditions

Ailim Activity

N/A

Tag

Ailim Contains A 6x histidine tag

Ailim Formulation

Liquid

Ailim Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Ailim family

-

Ailim Subcellular locations

Membrane; Single-pass type I membrane protein.

Ailim FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

Ailim Sequence

DDBJ

EMBL

GenBank

Ailim 3D structure

ModBase

Ailim interaction

STRING

Ailim Proteomic

PRIDE

Ailim Genome annotation

Ensembl

GeneID

KEGG

UCSC

Ailim Organism specific

CTD

MGI

Ailim Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Ailim Gene expression

Bgee

ArrayExpress

Genevestigator

Ailim Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY