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Mouse Heart- and neural crest derivatives-expressed 2 (aa 1-217)
Dhand Swiss Prot#
Q61039
Dhand Protein names
Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2)
Dhand Gene names
Hand2 (Dhand) (Hed) (Thing2)
Organism
Mouse
Dhand Entry name
HAND2_MOUSE
Dhand Codon optimized cDNA(gene) Clone
Dhand Cat #
RPU0205
Tag
Dhand contains A 6x histidine tag
Dhand Formulation
Liquid
Dhand Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Dhand Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Dhand Protein
Dhand Cat #
PU0205
Dhand Source
recombinant
Dhand Applications
Western Blot, SDS-Page or may be used for other applications determined by user
Dhand Purity
>90%, as determined by SDS-PAGE under reducing conditions
Dhand Activity
N/A
Tag
Dhand Contains A 6x histidine tag
Dhand Formulation
Liquid
Dhand Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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Dhand family
-
Dhand Subcellular locations
Nucleus.
Dhand FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
Dhand Sequence
DDBJ EMBL GenBank
Dhand 3D structure
ModBase
Dhand interaction
STRING
Dhand Proteomic
PRIDE
Dhand Genome annotation
Ensembl GeneID KEGG UCSC
Dhand Organism specific
CTD MGI
Dhand Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Dhand Gene expression
Bgee ArrayExpress Genevestigator
Dhand Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY