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Mouse Glucagon (aa 21-180)

Gcg Swiss Prot#

P55095

Gcg Protein names

Glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP) Oxyntomodulin (OXY) (OXM) Glucagon; Glucagon-like peptide 1 (GLP-1) Glucagon-like peptide 1(7-37) (GLP-1(7-37)) Glucagon-like peptide 1(7-36) (GLP-1(7-36)) Glucagon-like peptide 2 (GLP-2)]

Gcg Gene names

Gcg

Organism

Mouse

Gcg Entry name

GLUC_MOUSE

Gcg Codon optimized cDNA(gene) Clone

Gcg Cat #

RPU0199

Tag

Gcg contains A 6x histidine tag

Gcg Formulation

Liquid

Gcg Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Gcg Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Gcg Protein

Gcg Cat #

PU0199

Gcg Source

recombinant

Gcg Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Gcg Purity

>90%, as determined by SDS-PAGE under reducing conditions

Gcg Activity

N/A

Tag

Gcg Contains A 6x histidine tag

Gcg Formulation

Liquid

Gcg Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Gcg family

Glucagon family

Gcg Subcellular locations

Secreted.

Gcg FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity).; FUNCTION: GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferaton (By similarity).; FUNCTION: GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability (By similarity).; FUNCTION: Oxyntomodulin significantly reduces food intake (By similarity).; FUNCTION: Glicentin may modulate gastric acid secretion and gastro-pyloro-duodenal activity.

Gcg Sequence

DDBJ

EMBL

GenBank

Gcg 3D structure

ModBase

Gcg interaction

STRING

Gcg Proteomic

PRIDE

Gcg Genome annotation

Ensembl

GeneID

KEGG

UCSC

Gcg Organism specific

CTD

MGI

Gcg Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Gcg Gene expression

Bgee

ArrayExpress

Genevestigator

Gcg Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY