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Mouse Cyclin-dependent kinase inhibitor 2A isoform 3 (aa 1-169)

Cdkn2a Swiss Prot#

Q64364

Cdkn2a Protein names

Cyclin-dependent kinase inhibitor 2A, isoform 3 (p19ARF)

Cdkn2a Gene names

Cdkn2a

Organism

Mouse

Cdkn2a Entry name

CD2A2_MOUSE

Cdkn2a Codon optimized cDNA(gene) Clone

Cdkn2a Cat #

RPU0166

Tag

Cdkn2a contains A 6x histidine tag

Cdkn2a Formulation

Liquid

Cdkn2a Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cdkn2a Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cdkn2a Protein

Cdkn2a Cat #

PU0166

Cdkn2a Source

recombinant

Cdkn2a Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cdkn2a Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cdkn2a Activity

N/A

Tag

Cdkn2a Contains A 6x histidine tag

Cdkn2a Formulation

Liquid

Cdkn2a Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cdkn2a family

-

Cdkn2a Subcellular locations

Nucleus > nucleolus. Nucleus > nucleoplasm.

Cdkn2a FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination (By similarity). Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.

Cdkn2a Sequence

DDBJ

EMBL

GenBank

Cdkn2a 3D structure

ModBase

Cdkn2a interaction

STRING

Cdkn2a Proteomic

PRIDE

Cdkn2a Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cdkn2a Organism specific

CTD

MGI

Cdkn2a Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cdkn2a Gene expression

Bgee

ArrayExpress

Genevestigator

Cdkn2a Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY