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Mouse Cyclin-dependent kinase inhibitor 1 (aa 2-159)

Cip1 Swiss Prot#

P39689

Cip1 Protein names

Cyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1) (Melanoma differentiation-associated protein)

Cip1 Gene names

Cdkn1a (Cip1) (Waf1)

Organism

Mouse

Cip1 Entry name

CDN1A_MOUSE

Cip1 Codon optimized cDNA(gene) Clone

Cip1 Cat #

RPU0164

Tag

Cip1 contains A 6x histidine tag

Cip1 Formulation

Liquid

Cip1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cip1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cip1 Protein

Cip1 Cat #

PU0164

Cip1 Source

recombinant

Cip1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cip1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cip1 Activity

N/A

Tag

Cip1 Contains A 6x histidine tag

Cip1 Formulation

Liquid

Cip1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cip1 family

CDI family

Cip1 Subcellular locations

Cytoplasm. Nucleus.

Cip1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).

Cip1 Sequence

DDBJ

EMBL

GenBank

Cip1 3D structure

ModBase

Cip1 interaction

STRING

Cip1 Proteomic

PRIDE

Cip1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cip1 Organism specific

CTD

MGI

Cip1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cip1 Gene expression

Bgee

ArrayExpress

Genevestigator

Cip1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY