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Human Zinc finger protein ZIC 2 (aa 1-532 )

ZIC2 Swiss Prot#

O95409

ZIC2 Protein names

Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2)

ZIC2 Gene names

ZIC2

Organism

Human

ZIC2 Entry name

ZIC2_HUMAN

ZIC2 Codon optimized cDNA(gene) Clone

ZIC2 Cat #

RPU0120

Tag

ZIC2 contains A 6x histidine tag

ZIC2 Formulation

Liquid

ZIC2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ZIC2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ZIC2 Protein

ZIC2 Cat #

PU0120

ZIC2 Source

recombinant

ZIC2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ZIC2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ZIC2 Activity

N/A

Tag

ZIC2 Contains A 6x histidine tag

ZIC2 Formulation

Liquid

ZIC2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ZIC2 family

GLI C2H2-type zinc-finger protein family

ZIC2 Subcellular locations

Nucleus. Cytoplasm.

ZIC2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.

ZIC2 Sequence

DDBJ

EMBL

GenBank

ZIC2 3D structure

ModBase

ZIC2 interaction

STRING

ZIC2 Proteomic

PRIDE

ZIC2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ZIC2 Organism specific

CTD

MGI

ZIC2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ZIC2 Gene expression

Bgee

ArrayExpress

Genevestigator

ZIC2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY