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Human Tissue-type plasminogen activator (aa 23-562)

PLAT Swiss Prot#

P00750

PLAT Protein names

Tissue-type plasminogen activator (t-plasminogen activator) (t-PA) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]

PLAT Gene names

PLAT

Organism

Human

PLAT Entry name

TPA_HUMAN

PLAT Codon optimized cDNA(gene) Clone

PLAT Cat #

RPU0113

Tag

PLAT contains A 6x histidine tag

PLAT Formulation

Liquid

PLAT Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PLAT Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PLAT Protein

PLAT Cat #

PU0113

PLAT Source

recombinant

PLAT Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PLAT Purity

>90%, as determined by SDS-PAGE under reducing conditions

PLAT Activity

N/A

Tag

PLAT Contains A 6x histidine tag

PLAT Formulation

Liquid

PLAT Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PLAT family

Peptidase S1 family

PLAT Subcellular locations

Secreted > extracellular space.

PLAT FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migration.

PLAT Sequence

DDBJ

EMBL

GenBank

PLAT 3D structure

ModBase

PLAT interaction

STRING

PLAT Proteomic

PRIDE

PLAT Genome annotation

Ensembl

GeneID

KEGG

UCSC

PLAT Organism specific

CTD

MGI

PLAT Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PLAT Gene expression

Bgee

ArrayExpress

Genevestigator

PLAT Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY