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Human CASP8 and FADD-like apoptosis regulator (aa 1-480)

CASH Swiss Prot#

O15519

CASH Protein names

CASP8 and FADD-like apoptosis regulator (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]

CASH Gene names

CFLAR (CASH) (CASP8AP1) (CLARP) (MRIT)

Organism

Human

CASH Entry name

CFLAR_HUMAN

CASH Codon optimized cDNA(gene) Clone

CASH Cat #

RPU0014

Tag

CASH contains A 6x histidine tag

CASH Formulation

Liquid

CASH Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CASH Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CASH Protein

CASH Cat #

PU0014

CASH Source

recombinant

CASH Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CASH Purity

>90%, as determined by SDS-PAGE under reducing conditions

CASH Activity

N/A

Tag

CASH Contains A 6x histidine tag

CASH Formulation

Liquid

CASH Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CASH family

Peptidase C14A family

CASH Subcellular locations

-

CASH FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

CASH Sequence

DDBJ

EMBL

GenBank

CASH 3D structure

ModBase

CASH interaction

STRING

CASH Proteomic

PRIDE

CASH Genome annotation

Ensembl

GeneID

KEGG

UCSC

CASH Organism specific

CTD

MGI

CASH Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CASH Gene expression

Bgee

ArrayExpress

Genevestigator

CASH Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY