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Rat G1 S-specific cyclin-D3 (aa 1-293)

Ccnd3 Swiss Prot#

P48961

Ccnd3 Protein names

G1/S-specific cyclin-D3

Ccnd3 Gene names

Ccnd3

Organism

Rattus norvegicus (Rat)

Ccnd3 Entry name

CCND3_RAT

Ccnd3 Codon optimized cDNA(gene) Clone

Ccnd3 Cat #

RPM0574

Tag

Ccnd3 contains A 6x histidine tag

Ccnd3 Formulation

Liquid

Ccnd3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Ccnd3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Ccnd3 Protein

Ccnd3 Cat #

PM0574

Ccnd3 Source

recombinant

Ccnd3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Ccnd3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Ccnd3 Activity

N/A

Tag

Ccnd3 Contains A 6x histidine tag

Ccnd3 Formulation

Liquid

Ccnd3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Ccnd3 family

Cyclin family, Cyclin D subfamily

Ccnd3 Subcellular locations

Nucleus. Cytoplasm. Membrane.

Ccnd3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Ccnd3 Sequence

DDBJ

EMBL

GenBank

Ccnd3 3D structure

ModBase

Ccnd3 interaction

STRING

Ccnd3 Proteomic

PRIDE

Ccnd3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Ccnd3 Organism specific

CTD

MGI

Ccnd3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Ccnd3 Gene expression

Bgee

ArrayExpress

Genevestigator

Ccnd3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY