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Rat E3 ubiquitin-protein ligase SIAH1 (aa 1-282)

Siah1a Swiss Prot#

Q920M9

Siah1a Protein names

E3 ubiquitin-protein ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)

Siah1a Gene names

Siah1 (Siah1a)

Organism

Rattus norvegicus (Rat)

Siah1a Entry name

SIAH1_RAT

Siah1a Codon optimized cDNA(gene) Clone

Siah1a Cat #

RPM0573

Tag

Siah1a contains A 6x histidine tag

Siah1a Formulation

Liquid

Siah1a Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Siah1a Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Siah1a Protein

Siah1a Cat #

PM0573

Siah1a Source

recombinant

Siah1a Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Siah1a Purity

>90%, as determined by SDS-PAGE under reducing conditions

Siah1a Activity

N/A

Tag

Siah1a Contains A 6x histidine tag

Siah1a Formulation

Liquid

Siah1a Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Siah1a family

SINA (Seven in absentia) family

Siah1a Subcellular locations

Cytoplasm. Nucleus.

Siah1a FUNCTION According to UniProtKB Swiss Prot

FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.

Siah1a Sequence

DDBJ

EMBL

GenBank

Siah1a 3D structure

ModBase

Siah1a interaction

STRING

Siah1a Proteomic

PRIDE

Siah1a Genome annotation

Ensembl

GeneID

KEGG

UCSC

Siah1a Organism specific

CTD

MGI

Siah1a Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Siah1a Gene expression

Bgee

ArrayExpress

Genevestigator

Siah1a Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY