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Mouse Dickkopf-related protein 3 (aa 23-349)
Dkk3 Swiss Prot#
Q9QUN9
Dkk3 Protein names
Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (mDkk-3)
Dkk3 Gene names
Dkk3
Organism
Mus musculus (Mouse)
Dkk3 Entry name
DKK3_MOUSE
Dkk3 Codon optimized cDNA(gene) Clone
Dkk3 Cat #
RPM0422
Tag
Dkk3 contains A 6x histidine tag
Dkk3 Formulation
Liquid
Dkk3 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Dkk3 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Dkk3 Protein
Dkk3 Cat #
PM0422
Dkk3 Source
recombinant
Dkk3 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
Dkk3 Purity
>90%, as determined by SDS-PAGE under reducing conditions
Dkk3 Activity
N/A
Tag
Dkk3 Contains A 6x histidine tag
Dkk3 Formulation
Liquid
Dkk3 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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Dkk3 family
Dickkopf family
Dkk3 Subcellular locations
Secreted.
Dkk3 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease (By similarity).
Dkk3 Sequence
DDBJ EMBL GenBank
Dkk3 3D structure
ModBase
Dkk3 interaction
STRING
Dkk3 Proteomic
PRIDE
Dkk3 Genome annotation
Ensembl GeneID KEGG UCSC
Dkk3 Organism specific
CTD MGI
Dkk3 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Dkk3 Gene expression
Bgee ArrayExpress Genevestigator
Dkk3 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY