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Mouse Protein Wnt-5a (aa 62-380)

Wnt-5a Swiss Prot#

P22725

Wnt-5a Protein names

Protein Wnt-5a

Wnt-5a Gene names

Wnt5a (Wnt-5a)

Organism

Mus musculus (Mouse)

Wnt-5a Entry name

WNT5A_MOUSE

Wnt-5a Codon optimized cDNA(gene) Clone

Wnt-5a Cat #

RPM0405

Tag

Wnt-5a contains A 6x histidine tag

Wnt-5a Formulation

Liquid

Wnt-5a Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Wnt-5a Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Wnt-5a Protein

Wnt-5a Cat #

PM0405

Wnt-5a Source

recombinant

Wnt-5a Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Wnt-5a Purity

>90%, as determined by SDS-PAGE under reducing conditions

Wnt-5a Activity

N/A

Tag

Wnt-5a Contains A 6x histidine tag

Wnt-5a Formulation

Liquid

Wnt-5a Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Wnt-5a family

Wnt family

Wnt-5a Subcellular locations

Secreted > extracellular space > extracellular matrix.

Wnt-5a FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

Wnt-5a Sequence

DDBJ

EMBL

GenBank

Wnt-5a 3D structure

ModBase

Wnt-5a interaction

STRING

Wnt-5a Proteomic

PRIDE

Wnt-5a Genome annotation

Ensembl

GeneID

KEGG

UCSC

Wnt-5a Organism specific

CTD

MGI

Wnt-5a Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Wnt-5a Gene expression

Bgee

ArrayExpress

Genevestigator

Wnt-5a Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY