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Mouse E3 SUMO-protein ligase PIAS4 (aa 1-507)

Piasg Swiss Prot#

Q9JM05

Piasg Protein names

E3 SUMO-protein ligase PIAS4 (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) (PIASy)

Piasg Gene names

Pias4 (Piasg)

Organism

Mus musculus (Mouse)

Piasg Entry name

PIAS4_MOUSE

Piasg Codon optimized cDNA(gene) Clone

Piasg Cat #

RPM0383

Tag

Piasg contains A 6x histidine tag

Piasg Formulation

Liquid

Piasg Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Piasg Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Piasg Protein

Piasg Cat #

PM0383

Piasg Source

recombinant

Piasg Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Piasg Purity

>90%, as determined by SDS-PAGE under reducing conditions

Piasg Activity

N/A

Tag

Piasg Contains A 6x histidine tag

Piasg Formulation

Liquid

Piasg Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Piasg family

PIAS family

Piasg Subcellular locations

Nucleus > PML body.

Piasg FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses Lef1 and enhances TCF4 transcriptional activities.

Piasg Sequence

DDBJ

EMBL

GenBank

Piasg 3D structure

ModBase

Piasg interaction

STRING

Piasg Proteomic

PRIDE

Piasg Genome annotation

Ensembl

GeneID

KEGG

UCSC

Piasg Organism specific

CTD

MGI

Piasg Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Piasg Gene expression

Bgee

ArrayExpress

Genevestigator

Piasg Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY