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Mouse DNA methyltransferase 1-associated protein 1 (aa 1-468)

Mmtr Swiss Prot#

Q9JI44

Mmtr Protein names

DNA methyltransferase 1-associated protein 1 (DNMT1-associated protein 1) (DNMAP1) (MAT1-mediated transcriptional repressor)

Mmtr Gene names

Dmap1 (Mmtr)

Organism

Mus musculus (Mouse)

Mmtr Entry name

DMAP1_MOUSE

Mmtr Codon optimized cDNA(gene) Clone

Mmtr Cat #

RPM0377

Tag

Mmtr contains A 6x histidine tag

Mmtr Formulation

Liquid

Mmtr Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Mmtr Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Mmtr Protein

Mmtr Cat #

PM0377

Mmtr Source

recombinant

Mmtr Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Mmtr Purity

>90%, as determined by SDS-PAGE under reducing conditions

Mmtr Activity

N/A

Tag

Mmtr Contains A 6x histidine tag

Mmtr Formulation

Liquid

Mmtr Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Mmtr family

-

Mmtr Subcellular locations

Nucleus.

Mmtr FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity).

Mmtr Sequence

DDBJ

EMBL

GenBank

Mmtr 3D structure

ModBase

Mmtr interaction

STRING

Mmtr Proteomic

PRIDE

Mmtr Genome annotation

Ensembl

GeneID

KEGG

UCSC

Mmtr Organism specific

CTD

MGI

Mmtr Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Mmtr Gene expression

Bgee

ArrayExpress

Genevestigator

Mmtr Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY