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Mouse Core histone macro-H2A.1 (aa 2-372)

H2afy Swiss Prot#

Q9QZQ8

H2afy Protein names

Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y)

H2afy Gene names

H2afy

Organism

Mus musculus (Mouse)

H2afy Entry name

H2AY_MOUSE

H2afy Codon optimized cDNA(gene) Clone

H2afy Cat #

RPM0361

Tag

H2afy contains A 6x histidine tag

H2afy Formulation

Liquid

H2afy Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

H2afy Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant H2afy Protein

H2afy Cat #

PM0361

H2afy Source

recombinant

H2afy Applications

Western Blot, SDS-Page or may be used for other applications determined by user

H2afy Purity

>90%, as determined by SDS-PAGE under reducing conditions

H2afy Activity

N/A

Tag

H2afy Contains A 6x histidine tag

H2afy Formulation

Liquid

H2afy Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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H2afy family

-

H2afy Subcellular locations

Nucleus. Chromosome.

H2afy FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.

H2afy Sequence

DDBJ

EMBL

GenBank

H2afy 3D structure

ModBase

H2afy interaction

STRING

H2afy Proteomic

PRIDE

H2afy Genome annotation

Ensembl

GeneID

KEGG

UCSC

H2afy Organism specific

CTD

MGI

H2afy Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

H2afy Gene expression

Bgee

ArrayExpress

Genevestigator

H2afy Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY