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Mouse Importin subunit alpha-1 (aa 1-538)

Rch2 Swiss Prot#

Q60960

Rch2 Protein names

Importin subunit alpha-1 (Karyopherin subunit alpha-1) (SRP1-beta) (RAG cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1)

Rch2 Gene names

Kpna1 (Rch2)

Organism

Mus musculus (Mouse)

Rch2 Entry name

IMA1_MOUSE

Rch2 Codon optimized cDNA(gene) Clone

Rch2 Cat #

RPM0316

Tag

Rch2 contains A 6x histidine tag

Rch2 Formulation

Liquid

Rch2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Rch2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Rch2 Protein

Rch2 Cat #

PM0316

Rch2 Source

recombinant

Rch2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Rch2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Rch2 Activity

N/A

Tag

Rch2 Contains A 6x histidine tag

Rch2 Formulation

Liquid

Rch2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Rch2 family

Importin alpha family

Rch2 Subcellular locations

Cytoplasm. Nucleus.

Rch2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Rch2 Sequence

DDBJ

EMBL

GenBank

Rch2 3D structure

ModBase

Rch2 interaction

STRING

Rch2 Proteomic

PRIDE

Rch2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Rch2 Organism specific

CTD

MGI

Rch2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Rch2 Gene expression

Bgee

ArrayExpress

Genevestigator

Rch2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY