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Human Dickkopf-related protein 2 (aa 34-259)

DKK2 Swiss Prot#

Q9UBU2

DKK2 Protein names

Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)

DKK2 Gene names

DKK2 (UNQ682/PRO1316)

Organism

Homo sapiens (Human)

DKK2 Entry name

DKK2_HUMAN

DKK2 Codon optimized cDNA(gene) Clone

DKK2 Cat #

RPM0160

Tag

DKK2 contains A 6x histidine tag

DKK2 Formulation

Liquid

DKK2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

DKK2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant DKK2 Protein

DKK2 Cat #

PM0160

DKK2 Source

recombinant

DKK2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

DKK2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

DKK2 Activity

N/A

Tag

DKK2 Contains A 6x histidine tag

DKK2 Formulation

Liquid

DKK2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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DKK2 family

Dickkopf family

DKK2 Subcellular locations

Secreted.

DKK2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

DKK2 Sequence

DDBJ

EMBL

GenBank

DKK2 3D structure

ModBase

DKK2 interaction

STRING

DKK2 Proteomic

PRIDE

DKK2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

DKK2 Organism specific

CTD

MGI

DKK2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

DKK2 Gene expression

Bgee

ArrayExpress

Genevestigator

DKK2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY