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Human Dickkopf-related protein 4 (aa 19-224 )

DKK4 Swiss Prot#

Q9UBT3

DKK4 Protein names

Dickkopf-related protein 4 (Dickkopf-4) (Dkk-4) (hDkk-4) [Cleaved into: Dickkopf-related protein 4 short form]

DKK4 Gene names

DKK4

Organism

Homo sapiens (Human)

DKK4 Entry name

DKK4_HUMAN

DKK4 Codon optimized cDNA(gene) Clone

DKK4 Cat #

RPM0157

Tag

DKK4 contains A 6x histidine tag

DKK4 Formulation

Liquid

DKK4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

DKK4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant DKK4 Protein

DKK4 Cat #

PM0157

DKK4 Source

recombinant

DKK4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

DKK4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

DKK4 Activity

N/A

Tag

DKK4 Contains A 6x histidine tag

DKK4 Formulation

Liquid

DKK4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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DKK4 family

Dickkopf family

DKK4 Subcellular locations

Secreted.

DKK4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

DKK4 Sequence

DDBJ

EMBL

GenBank

DKK4 3D structure

ModBase

DKK4 interaction

STRING

DKK4 Proteomic

PRIDE

DKK4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

DKK4 Organism specific

CTD

MGI

DKK4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

DKK4 Gene expression

Bgee

ArrayExpress

Genevestigator

DKK4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY