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Human Mothers against decapentaplegic homolog 7 (aa 1-426)

MADH7 Swiss Prot#

O15105

MADH7 Protein names

Mothers against decapentaplegic homolog 7 (Mothers against DPP homolog 7) (SMAD 7) (Smad7) (hSMAD7)

MADH7 Gene names

SMAD7 (MADH7) (MADH8)

Organism

Homo sapiens (Human)

MADH7 Entry name

SMAD7_HUMAN

MADH7 Codon optimized cDNA(gene) Clone

MADH7 Cat #

RPM0128

Tag

MADH7 contains A 6x histidine tag

MADH7 Formulation

Liquid

MADH7 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MADH7 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MADH7 Protein

MADH7 Cat #

PM0128

MADH7 Source

recombinant

MADH7 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MADH7 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MADH7 Activity

N/A

Tag

MADH7 Contains A 6x histidine tag

MADH7 Formulation

Liquid

MADH7 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MADH7 family

Dwarfin/SMAD family

MADH7 Subcellular locations

Nucleus. Cytoplasm.

MADH7 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.

MADH7 Sequence

DDBJ

EMBL

GenBank

MADH7 3D structure

ModBase

MADH7 interaction

STRING

MADH7 Proteomic

PRIDE

MADH7 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MADH7 Organism specific

CTD

MGI

MADH7 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MADH7 Gene expression

Bgee

ArrayExpress

Genevestigator

MADH7 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY