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Human Histone acetyltransferase HTATIP (aa 1-513)

TIP60 Swiss Prot#

Q92993

TIP60 Protein names

Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60) (HIV-1 Tat interactive protein) (cPLA(2)-interacting protein)

TIP60 Gene names

HTATIP (TIP60)

Organism

Homo sapiens (Human)

TIP60 Entry name

KAT5_HUMAN

TIP60 Codon optimized cDNA(gene) Clone

TIP60 Cat #

RPM0127

Tag

TIP60 contains A 6x histidine tag

TIP60 Formulation

Liquid

TIP60 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TIP60 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TIP60 Protein

TIP60 Cat #

PM0127

TIP60 Source

recombinant

TIP60 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TIP60 Purity

>90%, as determined by SDS-PAGE under reducing conditions

TIP60 Activity

N/A

Tag

TIP60 Contains A 6x histidine tag

TIP60 Formulation

Liquid

TIP60 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TIP60 family

MYST (SAS/MOZ) family

TIP60 Subcellular locations

Nucleus > nucleolus. Cytoplasm > perinuclear region.

TIP60 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

TIP60 Sequence

DDBJ

EMBL

GenBank

TIP60 3D structure

ModBase

TIP60 interaction

STRING

TIP60 Proteomic

PRIDE

TIP60 Genome annotation

Ensembl

GeneID

KEGG

UCSC

TIP60 Organism specific

CTD

MGI

TIP60 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TIP60 Gene expression

Bgee

ArrayExpress

Genevestigator

TIP60 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY