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Human Lymphoid enhancer-binding factor 1 (aa 1-399)

LEF1 Swiss Prot#

Q9UJU2

LEF1 Protein names

Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)

LEF1 Gene names

LEF1

Organism

Homo sapiens (Human)

LEF1 Entry name

LEF1_HUMAN

LEF1 Codon optimized cDNA(gene) Clone

LEF1 Cat #

RPM0108

Tag

LEF1 contains A 6x histidine tag

LEF1 Formulation

Liquid

LEF1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

LEF1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant LEF1 Protein

LEF1 Cat #

PM0108

LEF1 Source

recombinant

LEF1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

LEF1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

LEF1 Activity

N/A

Tag

LEF1 Contains A 6x histidine tag

LEF1 Formulation

Liquid

LEF1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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LEF1 family

TCF/LEF family

LEF1 Subcellular locations

Nucleus.

LEF1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

LEF1 Sequence

DDBJ

EMBL

GenBank

LEF1 3D structure

ModBase

LEF1 interaction

STRING

LEF1 Proteomic

PRIDE

LEF1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

LEF1 Organism specific

CTD

MGI

LEF1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

LEF1 Gene expression

Bgee

ArrayExpress

Genevestigator

LEF1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY