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Human Protein arginine N-methyltransferase 1 (aa 1-361)

HMT2 Swiss Prot#

Q99873

HMT2 Protein names

Protein arginine N-methyltransferase 1 (EC 2.1.1.-) (Interferon receptor 1-bound protein 4)

HMT2 Gene names

PRMT1 (HMT2) (HRMT1L2) (IR1B4)

Organism

Homo sapiens (Human)

HMT2 Entry name

ANM1_HUMAN

HMT2 Codon optimized cDNA(gene) Clone

HMT2 Cat #

RPM0106

Tag

HMT2 contains A 6x histidine tag

HMT2 Formulation

Liquid

HMT2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

HMT2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant HMT2 Protein

HMT2 Cat #

PM0106

HMT2 Source

recombinant

HMT2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

HMT2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

HMT2 Activity

N/A

Tag

HMT2 Contains A 6x histidine tag

HMT2 Formulation

Liquid

HMT2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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HMT2 family

Protein arginine N-methyltransferase family

HMT2 Subcellular locations

Nucleus. Cytoplasm > cytosol.

HMT2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.

HMT2 Sequence

DDBJ

EMBL

GenBank

HMT2 3D structure

ModBase

HMT2 interaction

STRING

HMT2 Proteomic

PRIDE

HMT2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

HMT2 Organism specific

CTD

MGI

HMT2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

HMT2 Gene expression

Bgee

ArrayExpress

Genevestigator

HMT2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY