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Human Glutaredoxin-2 mitochondrial (aa 20- 64)

GRX2 Swiss Prot#

Q9NS18

GRX2 Protein names

Glutaredoxin-2, mitochondrial

GRX2 Gene names

GLRX2 (GRX2) (CGI-133)

Organism

Homo sapiens (Human)

GRX2 Entry name

GLRX2_HUMAN

GRX2 Codon optimized cDNA(gene) Clone

GRX2 Cat #

RPM0080

Tag

GRX2 contains A 6x histidine tag

GRX2 Formulation

Liquid

GRX2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

GRX2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant GRX2 Protein

GRX2 Cat #

PM0080

GRX2 Source

recombinant

GRX2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

GRX2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

GRX2 Activity

N/A

Tag

GRX2 Contains A 6x histidine tag

GRX2 Formulation

Liquid

GRX2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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GRX2 family

Glutaredoxin family

GRX2 Subcellular locations

Mitochondrion. Nucleus.

GRX2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

GRX2 Sequence

DDBJ

EMBL

GenBank

GRX2 3D structure

ModBase

GRX2 interaction

STRING

GRX2 Proteomic

PRIDE

GRX2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

GRX2 Organism specific

CTD

MGI

GRX2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

GRX2 Gene expression

Bgee

ArrayExpress

Genevestigator

GRX2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY